Adrenocorticosteroids

Adrenocorticosteroids and Adrenocortical Antagonists Ma. Victoria M. Villarica, M.D. Fatima College of Medicine

Objectives ,[object Object],[object Object],[object Object]

Types of steroid hormones ,[object Object],[object Object],[object Object],[object Object],[object Object]

Adrenal Gland ,[object Object],[object Object]

Adrenal Cortex ,[object Object],[object Object],[object Object],[object Object]

ACTH ,[object Object],[object Object],[object Object],[object Object]

ACTH ,[object Object],[object Object]

Regulation of ACTH secretion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Control of Endocrine Activity ,[object Object],[object Object]

[object Object],[object Object],Steroid hormones

cholesterol Extracellular lipoprotein Cholesterol pool LH ATP cAMP PKA+ Pregnenolone Progesterone Androstenedione TESTOSTERONE 3  HSD P450c17 17  HSD acetate

Steroid hormone production ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Steroidogenic Enzymes Common name "Old" name Current name Side-chain cleavage enzyme; desmolase P450 SCC CYP11A1 3 beta-hydroxysteroid dehydrogenase 3 beta-HSD 3 beta-HSD 17 alpha-hydroxylase/17,20 lyase P450 C17 CYP17 21-hydroxylase P450 C21 CYP21A2 11 beta-hydroxylase P450 C11 CYP11B1 Aldosterone synthase P450 C11AS CYP11B2 Aromatase P450 aro CYP19

Adrenocorticosteroids ,[object Object],[object Object],[object Object],[object Object]

A. Mineralocorticoids ,[object Object],[object Object],[object Object],[object Object],[object Object]

B. Glucocorticoids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CBG (transcortin) ,[object Object],[object Object]

C. Adrenal Androgens ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

Physiologic effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Physiologic effects (cont.): ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Physiologic effects (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Physiologic effects (cont.): ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Synthetic Steroids ,[object Object],[object Object],[object Object],[object Object]

Classification of Glucocorticoids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

II. Intermediate-acting glucocorticoids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],IV. Mineralocorticoids

Uses: ,[object Object],[object Object]

Therapeutic Uses : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

1. Adrenal Insufficiency (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Therapeutic Uses (cont.) 2. Adrenocortical hypofunctioning and hyperfunctioning ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Therapeutic Uses 2. Adrenocortical hypofunctioning and hyperfunctioning (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

B. Stimulation of fetal lung maturation – betamethasone 12mg ffed by 12mg 18-24 hrs. later ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

C. Non-Adrenal Diseases (cont.) ,[object Object],[object Object],[object Object],[object Object]

C. Non- Adrenal Diseases (cont.) ,[object Object],[object Object]

C. Non-Adrenal Diseases (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object]

C. Non-Adrenal Diseases (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

C. Non-Adrenal Diseases (cont.) ,[object Object],[object Object],[object Object]

D. Diagnostic Application – dexamethasone: suppress production of ACTH ,[object Object],[object Object],[object Object],[object Object],[object Object]

Toxicity: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Supplemental measures: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antagonists of Adrenocortical Agents ,[object Object],[object Object],[object Object],[object Object]

Synthetic inhibitors and glucocorticoid antagonists (cont.) ,[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Synthetic inhibitors and glucocorticoid antagonists (cont.)

[object Object],[object Object],[object Object],Synthetic inhibitors and glucocorticoid antagonists (cont.)

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Classification of topical corticosteroids based on their potencies ,[object Object],[object Object],[object Object],[object Object],[object Object]

Classification of topical corticosteroids based on their potencies (continued) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Classification of topical corticosteroids based on their potencies (continued) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Classification of topical corticosteroids based on their potencies (continued) ,[object Object],[object Object],[object Object],[object Object],[object Object]

Common side effects of topical corticosteroids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Summary of adrenocortical agonists and antagonists…… ,[object Object],[object Object],[object Object]

Adrenocorticosteroids

Recommended

Recommended

More Related Content

What's hot

What's hot (20)

Viewers also liked

Viewers also liked (20)

Similar to Adrenocorticosteroids

Similar to Adrenocorticosteroids (20)

More from MD Specialclass

More from MD Specialclass (20)

Recently uploaded

Recently uploaded (20)

Adrenocorticosteroids